Kukho izizathu ezininzi zokuphazamiseka kwesisu, kwaye ezona zixhaphakileyo zizigulane ezinamathumba ahlukeneyo anobungozi, ngakumbi izicubu ezinobungozi zesisu. Ngokwezibalo ezingaphelelanga, malunga ne-30% yezigulane ezineethumba ze-digestive tract ziya kufumana amanqanaba ahlukeneyo okuthintela, okukhokelela ngokuthe ngqo ekungakwazini kwezigulane ukutya ngokuqhelekileyo, kukhatshwa ziintlungu zesisu, ukudumba, kwaye kwiimeko ezinzima, ukutyhobozwa kwesisu, kunye nokuba iimeko ezibeka ubomi esichengeni.